The PAX 5 gene is frequently rearranged in BCR - ABL 1 - positive acute lymphoblastic leukemia but is not associated with outcome . A report on behalf of the GIMEMA Acute Leukemia Working
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Original Articles haematologica | 2010; 95(10) 1683 ©F err ata S tor ti F ou da tio n
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The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party.
BACKGROUND Recently, in genome-wide analyses of DNA copy number abnormalities using single nucleotide polymorphism microarrays, genetic alterations targeting PAX5 were identified in over 30% of pediatric patients with acute lymphoblastic leukemia. So far the occurrence of PAX5 alterations and their clinical correlation have not been investigated in adults with BCR-ABL1-positive acute lymphoblas...
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تاریخ انتشار 2010